DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes through three nucleotidyl transfer techniques involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal buildings of DNA ligases bound to nucleotide and nucleic acid substrates have illuminate... https://deniss455hcw1.evawiki.com/user