It is feasible that the TCAB1-mediated “switch” isn't captured with the conformation characterized during the cryo-EM structure. Characterizing a larger fraction on the holoenzyme particles from the active chromatographic fraction will likely result in the identification of extra conformational states. The cryo-EM characterization of human telomerase also reveals the presence https://saekimforum84715.xzblogs.com/69739431/detailed-notes-on-sanakin-tedavisi-yan-etkileri