At present, There's two types of studies on itaconate: Irg1−/− macrophages plus the regulatory result of itaconate derivatives. These two results have been complementary and disclosed the regulatory mechanisms of itaconate included alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription factor 3 (ATF3) induction to inhibit IκBζ https://francesk666xjt8.sasugawiki.com/user