Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators through the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have determined recurrent mutations in genes regulating tumor cell-microenvironment ... https://samueli297aiq4.ageeksblog.com/profile