Peripheral artery disease is generally an indication of the buildup of fatty deposits within the arteries, a situation referred to as atherosclerosis. Patients with important limb ischemia/Serious limb-threatening ischemia (CLI/CLTI) at risk for acquiring gangrene will existing with limb ache which has progressed from intermittent claudication with exertion to Serious rest https://sgvasculargrp.com/medical-condition/peripheral-arterial-disease/