There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lessen afferent pain transmission and produce analgesia. Therefore, drugs like clonidine that goal alpha-two receptors can impact the transmission of soreness. For people who get dizzy when standing: https://www.proleviate.com/post/the-new-pain-killer-conolidine